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} ], "entities": [], "headline": "Novartis Reports Phase III HARBOR Study for Del-desiran in DM1 Did Not Meet Primary Endpoint", "home_domain": null, "manifest_id": "1788911135167355990", "published_at": "2026-09-08", "significance": "high", "source_channel": "Novartis SEC Filings", "source_name": "sec-company-0001114448", "source_url": "https://www.sec.gov/Archives/edgar/data/1114448/000117184326005908/f6k_090826.htm", "stream_id": null, "stream_ids": [ "17723038993558045", "17817299983476143" ], "summary": "Novartis announced that its Phase III HARBOR study for delpacibart etedesiran (del-desiran) failed to meet its primary endpoint of video hand opening time (vHOT) in patients with myotonic dystrophy type 1 (DM1). 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